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James Collins presented data on the early interactions of Lactobacillus plantarum and Salmonella Typhimurium in a novel in vitro organ culture model. L. plantarum did not affect the interaction of Salmonella with IVOC tissues. There were some interesting changes in protein profile expressed in the tissues. Diane Newell presented data on the immune responses in chickens following immunization with candidate Campylobacter jejuni subunit vaccines. These vaccines induced significant protection against colonization. Serum antibodies only appeared after infection indicating that the vaccination protocol resulted in priming of an immune response which was difficult to monitor, but which did induce protection. Karin Lagesen presented on in silico mapping of and prediction of Campylobacter colonization factors. She followed a systems biology approach based on homology between strains the Campylobacter core genome. Within this core genome putative colonization factors were defined. This approach may lead to the prediction of putative colonization factors. Nadia Inglese presented data on cultivating Hepatitis E virus in vitro. In cell lines HEV does not replicate. She used an in vitro organ culture model for infection with HEV. In this model HEV replication was observed, thereby defining the albeit at a very slow rate. If this model can be developed further it can also be used to study the interaction of HEV with cells. Chair: Riny Janssen (RIVM)
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